Two sample MR report
LY86_Alveolar Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.0294038 | 0.0438652 | 0.5506388 |
| Weighted median | 5 | -0.0344644 | 0.0093499 | 0.0002277 |
| Inverse variance weighted | 5 | -0.0350010 | 0.0080885 | 0.0000151 |
| Simple mode | 5 | -0.0338749 | 0.0120813 | 0.0486173 |
| Weighted mode | 5 | -0.0338749 | 0.0117412 | 0.0447808 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0511086 | 3 | 0.9969737 |
| Inverse variance weighted | 0.0679634 | 4 | 0.9994355 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0042127 | 0.0324485 | 0.9049199 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005141 | 0 | TRUE | 0.0315407 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
